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Dr. Denis SlinkinMany of the world's leading scientific centres are researching HIV infection, using the latest technology and scientific discoveries, but many of the disease's mysteries remain unresolved. So far, it has not been possible to control and stabilize the HIV epidemic.

The short path to antiretroviral therapy (ART) has seen both dizzying success and unsuccessful attempts, says Dr. Denis Slinkin.

For a long time, azidotimidine (AZT) has been the most effective antiretroviral therapy available since 1987. Its therapeutic effect is based on blocking the virus's interaction with cells.

The virus loses the ability to multiply, as a result the number of viral particles in the body decreases and the number of blood cells responsible for immunity increases, the patient's condition improves.

However, the results of its use as a monopreparation did not meet expectations, as HIV produces resistance to the drug during prolonged treatment. The same happened with other drugs, reverse transcriptase inhibitors, which appeared in 1991-1994.

Dr. Denis Slinkin states: Life of people with HIV/AIDS around the world has often followed the inevitable course - the destruction of the immune system, the emergence of infectious (opportunistic) diseases, exhaustion, destruction of the nervous system and death.
Denis Slinkin
The emergence in 1996 of a new class of antiviral drugs for HIV protease inhibitors and their combined use with drugs from other classes changed the way people think about HIV/AIDS.

Today's reality just 10 years ago seemed impossible. HIV infection began to be seen as a chronic disease that, although incurable, could be successfully controlled by taking medication for life. Mortality and morbidity have dropped dramatically, and the quality and longevity of life for people living with HIV has improved.

Antiviral medication forms have become more convenient to take. ART treatment schemes are already in place, with a single daily dose of drugs.Today, doctors have more than 43 medicines for adults and 23 for children, says Dr. Denis Slinkin.

Academic Unit for Travel
Medicine & Vaccines
Royal Free & University
College Medical School,
Rowland Hill Street,
London NW3 2PF
Great Britain

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